Determining the risk of the other active ingredients found in Mucinex is a little trickier. Dextromethorphan is a cough suppressant that works by interfering with the "cough" signal in your brain. Guaifenesin works by loosening the mucus in your chest. There are some reports of a small risk of neural tube defects linked to guaifenesin, but the evidence is inconclusive. It's listed in a report by the American Academy of Family Physicians as "might be unsafe during first trimester." In the same report, dextromethorphan is listed as "appears to be safe in pregnancy," but as is true for many drugs and ingredients, there isn't enough evidence to say conclusively either way.

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